Treatment of advanced cutaneous T-cell lymphomas with non-pegylated liposomal doxorubicin - Consensus of the lymphoma group of the Working Group Dermatologic Oncology.
Jan 2013
Source
Department of Dermatlogy, Helios Clinic Krefeld, Germany Department of Dermatology and Venereology, University of Graz, Austria Department of Dermatolgogy, Venereology and Allergology, Charité- University Medicine Berlin, Germany Department of Dermatology, University Clinic Zurich, Switzerland Department of Dermatolgoy, Municipal Clinic Ludwigshaven, Germany Department of Dermatology, University of Mannheim, Germany Department of Dermatology and Venereology, University of Cologne, Germany Department of Dermatology, University of Kiel, Germany Department of Dermatolgy, Johannes Wesling Clinic Minden, Germany.
Abstract
Background: Systemic treatment with pegylated liposomal doxorubicin is an established second-line treatment of advancedcutaneous T-cell lymphoma. Pegylated liposomal doxorubicin (PLD) is currently unavailable, therefore, clinical studies investigating the efficacy of non-pegylated liposomal formula (NPLD) have been analyzed.
Methods: Since clinical trials comparing PLD and NPLD in CTCL do not exist, the clinical use of NPLD including safety and efficiency profile in other types of non-Hodgkin lymphoma were analyzed.
Results: Clinical trials show a comparable efficacy of NPLD and PLD in non-Hodgkin lymphoma. The dosage of NPLD used in the treatment of systemic lymphoma within polychemotherapy regimens was 50 mg/m(2) every three weeks. Overall response was 75-95 %, including a complete remission rate of 65-80 % and 2- and 3-year overall survival rates of 55-75 %. These data indicate that the non-pegylated formula of doxorubicin has a similar antitumor effect as the pegylated one but shows reduced cardiotoxicity. The palmoplantar erythrodysesthesia frequently observed in PLD has not been observed with the use of the NPLD.
Conclusions: The clinical use of NPLD in the treatment of CTCL is reasonable. In analogy to the clinical trials of NPLD in non-Hodgkin lymphoma a dosage of 50 mg/m(2) every three weeks is recommended for the treatment of CTCL.
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